![]() We have found no indication of a role of prenatal hormone exposure in female-to-male transsexualism. Our findings support a biological etiology of male-to-female transsexualism, implicating decreased prenatal androgen exposure in MFT. ![]() In FMT we found no differences in 2D:4D relative to control females. Comparison between right-handed individuals revealed that the right-hand 2D:4D in MFT is higher than in control males but similar to that observed in control females. PMCID: PMC5961159 DOI: 10.1093/hmg/ddy121 Abstract The ratio of the length of the index finger to that of the ring finger (2D:4D) is sexually dimorphic and is commonly used as a non-invasive biomarker of prenatal androgen exposure. Photo copies of the palms and digits of the hands were taken of all subjects and 2D:4D ratios were measured, according to standard published procedures. The following search was performed to identify papers published each year, with an example of 2020: (2D:4D or digit ratio) AND ((2020date-publication: 2020date-publication)). Sixty-three male-to-female transsexuals (MFT), 43 female-to-male transsexuals (FMT), and 65 female and 58 male controls were included in the study. Cumulative number of PubMed indexed papers about the second-to-fourth digit ratio (2D:4D). We wanted to assess differences in 2D:4D ratio between transsexuals and controls. ![]() The ratio of the 2nd to the 4th (2D:4D) digit lengths has been suggested to be negatively correlated to prenatal androgen exposure. Prenatal exposure to androgens has been implicated in transsexualism but the etiology of the condition remains unclear. ![]()
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